Imatinib induces autophagy throughBECLIN‐1andATG5genes in chronic myeloid leukemia cells

Content Provider	Scilit
Author	Can, Geylani Ekiz, Huseyin Atakan Baran, Yusuf
Copyright Year	2011
Description	Locate full-text(opens in a new window)|Full Text(opens in a new window)|View at Publisher| Export | Download | Add to List | More... Hematology Volume 16, Issue 2, March 2011, Pages 95-99 Imatinib induces autophagy through BECLIN-1 and ATG5 genes in chronic myeloid leukemia cells (Article) Can, G., Ekiz, H.A., Baran, Y. Department of Molecular Biology and Genetics, Faculty of Science, Izmir Institute of Technology, 35430 Urla, Izmir, Turkey View references (35) Abstract Imatinib is a chemotherapeutic drug used for the treatment of chronic myeloid leukemia (CML). Recent data showed imatinib-induced cell death in various types of cancers. Autophagy is the physiological process in which cellular components are broken down by the lysosomal activation. In this study, we aimed to examine the effects of imatinib on autophagy in addition to apoptosis in CML cells. Results suggested that imatinib induces autophagy in CML cells through inducing over-expression of BECLIN-1 and ATG5 genes with the statistical significance. Our results demonstrated that autophagy might be involved in imatinib-induced cell death.Turkish Academy of Science
Related Links	http://openaccess.iyte.edu.tr/bitstream/11147/5101/1/5101.pdf https://core.ac.uk/download/pdf/93242404.pdf
Ending Page	99
Page Count	5
Starting Page	95
ISSN	10245332
e-ISSN	16078454
DOI	10.1179/102453311x12902908412039
Journal	Hematology
Issue Number	2
Volume Number	16
Language	English
Publisher	Informa UK Limited
Publisher Date	2011-03-01
Access Restriction	Open
Subject Keyword	Hematology Cell Death Autophagy Apoptosis Window Imatinib Induces Treatment
Content Type	Text
Resource Type	Article
Subject	Hematology