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Methods for Gene Delivery to Neural Tissue
| Content Provider | Scilit |
|---|---|
| Author | Hampl, Jürgen A. Brown, Alice B. Rainov, Nikolai G. Breakefield, Xandra O. |
| Copyright Year | 2001 |
| Description | Gene delivery to the brain presents several unique challenges based on limited and risky access through the skull/vertebrae; sensitivity to volumetric changes; critical nuclei controlling life-functions; and a highly specialized blood-brain-barrier designed to keep particles and viruses out. The architectural heterogeneity of the neurocircuitry in the central nervous system (CNS) provides the opportunity to target focal areas of disease pathogenesis, but further complicates delivery for more global CNS diseases, such as brain tumors. This chapter will focus on modes of gene delivery to the nervous system, including vectors, cells, and routes of administration. Book Name: Methods in Genomic Neuroscience |
| Related Links | https://content.taylorfrancis.com/books/download?dac=C2010-0-33430-9&isbn=9780429126192&doi=10.1201/9781420038477-14&format=pdf |
| Ending Page | 266 |
| Page Count | 38 |
| Starting Page | 229 |
| DOI | 10.1201/9781420038477-14 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2001-09-26 |
| Access Restriction | Open |
| Subject Keyword | Book Name: Methods in Genomic Neuroscience Biomedical Engineering Neural Functions Nervous System Gene Delivery Controlling Life |
| Content Type | Text |
| Resource Type | Chapter |