Loading...
Please wait, while we are loading the content...
Similar Documents
Picroside II decreases the development of fibrosis induced by ischemia/reperfusion injury in rats
| Content Provider | Scilit |
|---|---|
| Author | Wang, Lei Liu, Xiu-Heng Chen, Hui Chen, Zhi-Yuan Weng, Xiao-Dong Qiu, Tao Liu, Lin |
| Copyright Year | 2014 |
| Description | In kidney transplantation, renal ischemia and reperfusion injury was one of the leading factors to the development of renal fibrosis, which was the main cause of graft loss. The fibrogenic changes were associated with the long term inflammation elicited by ischemia and reperfusion injury. In the present study, we investigated the role of the Picroside II, the main active constituents of the extract of picrorrhiza scrophulariiflora roots, in attenuating renal fibrosis in a renal ischemia and reperfusion injury model. We induced ischemia and reperfusion injury in kidneys treated with or without Picroside II. We observed that inflammation and tissue fibrosis were increased in ischemia and reperfusion injury group compared to Picroside II group, however, these changes were significantly decreased by the treatment with Picroside II. We concluded that Picroside II can protect the ischemic kidney against renal fibrosis and its mechanism may be through the inhibition of the long term inflammation. |
| Related Links | http://www.tandfonline.com/doi/pdf/10.3109/0886022X.2014.949766?needAccess=true |
| Ending Page | 1448 |
| Page Count | 6 |
| Starting Page | 1443 |
| ISSN | 0886022X |
| e-ISSN | 15256049 |
| DOI | 10.3109/0886022x.2014.949766 |
| Journal | Renal Failure |
| Issue Number | 9 |
| Volume Number | 36 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2014-08-12 |
| Access Restriction | Open |
| Subject Keyword | Toxicology Fibrosis Picroside Ii Inflammation Ischemia and Reperfusion Injury |
| Content Type | Text |
| Resource Type | Article |
| Subject | Critical Care and Intensive Care Medicine Nephrology |
