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Combining an Internal Pilot with an Interim Analysis for Single Degree of Freedom Tests
| Content Provider | Scilit |
|---|---|
| Author | Kairalla, John A. Muller, Keith E. Coffey, Christopher S. |
| Copyright Year | 2010 |
| Description | An internal pilot with interim analysis (IPIA) design combines interim power analysis (an internal pilot) with interim data analysis (two-stage group sequential). We provide IPIA methods for single df hypotheses within the Gaussian general linear model, including one and two group t tests. The design allows early stopping for efficacy and futility while also re-estimating sample size based on an interim variance estimate. Study planning in small samples requires the exact and computable forms reported here. The formulation gives fast and accurate calculations of power, Type I error rate, and expected sample size. |
| Related Links | http://europepmc.org/articles/pmc2965034?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965034/pdf |
| Ending Page | 3738 |
| Page Count | 22 |
| Starting Page | 3717 |
| ISSN | 03610926 |
| e-ISSN | 1532415X |
| DOI | 10.1080/03610920903353709 |
| Journal | Communications in Statistics - Theory and Methods |
| Issue Number | 20 |
| Volume Number | 39 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2010-09-22 |
| Access Restriction | Open |
| Subject Keyword | Mathematical Psychology Mathematical Social Sciences Adaptive Designs Sample Size Re-estimation |
| Content Type | Text |
| Resource Type | Article |
| Subject | Statistics and Probability |
