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Zerumbone-loaded nanostructured lipid carriers: preparation, characterization, and antileukemic effect
| Content Provider | Scilit |
|---|---|
| Author | Rahman, Heshu Sulaiman Rasedee, Abdullah How, Chee Wun Abdul, Ahmad Bustamam Allaudin, Zeenathul Nazariah Othman, Hemn Hassan Saeed, Mohamed Ibrahim Yeap, Swee Keong |
| Copyright Year | 2013 |
| Description | Zerumbone, a natural dietary lipophilic compound with low water solubility (1.296 mg/L at 25°C) was used in this investigation. The zerumbone was loaded into nanostructured lipid carriers using a hot, high-pressure homogenization technique. The physicochemical properties of the zerumbone-loaded nanostructured lipid carriers (ZER-NLC) were determined. The ZER-NLC particles had an average size of 52.68 ± 0.1 nm and a polydispersity index of 0.29 ± 0.004 µm. Transmission electron microscopy showed that the particles were spherical in shape. The zeta potential of the ZER-NLC was −25.03 ± 1.24 mV, entrapment efficiency was 99.03%, and drug loading was 7.92%. In vitro drug release of zerumbone from ZER-NLC was 46.7%, and for a pure zerumbone dispersion was 90.5% over 48 hours, following a zero equation. Using the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay in human T-cell acute lymphoblastic leukemia (Jurkat) cells, the half maximal inhibitory concentration $(IC_{50}$) of ZER-NLC was 5.64 ± 0.38 µg/mL, and for free zerumbone was 5.39 ± 0.43 µg/mL after 72 hours of treatment. This study strongly suggests that ZER-NLC have potential as a sustained-release drug carrier system for the treatment of leukemia. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3739459/pdf https://www.dovepress.com/getfile.php?fileID=16967 |
| Ending Page | 2781 |
| Page Count | 13 |
| Starting Page | 2769 |
| e-ISSN | 11782013 |
| DOI | 10.2147/ijn.s45313 |
| Journal | International Journal of Nanomedicine |
| Issue Number | 1 |
| Volume Number | 8 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2013-08-01 |
| Access Restriction | Open |
| Subject Keyword | Pharmacology and Pharmacy Zerumbone Nanostructured Lipid Carrier Leukemia |
| Content Type | Text |
| Resource Type | Article |
