Loading...
Please wait, while we are loading the content...
Similar Documents
Benralizumab: a unique IL-5 inhibitor for severe asthma
| Content Provider | Scilit |
|---|---|
| Author | Tan, Laren D. Gódor, Dorottya Bratt, Jennifer M. Kenyon, Nicholas J. Louie, Samuel |
| Copyright Year | 2016 |
| Description | Benralizumab: a unique IL-5 inhibitor for severe asthma Laren D Tan,1 Jennifer M Bratt,2 Dorottya Godor,3 Samuel Louie,2 Nicholas J Kenyon2 1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, School of Medicine, Loma Linda University, Loma Linda, CA, USA; 2Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, School of Medicine, University of California Davis, Sacramento, CA, USA; 3School of Medicine, Semmelweis University, Budapest, Hungary The presence of eosinophilic inflammation is a characteristic feature of chronic and acute inflammation in asthma. An estimated 5%–10% of the 300 million people worldwide who suffer from asthma have a severe form. Patients with eosinophilic airway inflammation represent approximately 40%–60% of this severe asthmatic population. This form of asthma is often uncontrolled, marked by refractoriness to standard therapy, and shows persistent airway eosinophilia despite glucocorticoid therapy. This paper reviews personalized novel therapies, more specifically benralizumab, a humanized anti-IL-5Rα antibody, while also being the first to provide an algorithm for potential candidates who may benefit from anti-IL-5Rα therapy. Keywords: asthma, eosinophils, asthma treatments, benralizumab, IL-5, IL-5Rα, MEDI-563 |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831605/pdf https://www.dovepress.com/getfile.php?fileID=29720 |
| Ending Page | 81 |
| Page Count | 11 |
| Starting Page | 71 |
| ISSN | 11786965 |
| DOI | 10.2147/jaa.s78049 |
| Journal | Journal of asthma and allergy |
| Volume Number | 9 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2016-04-01 |
| Access Restriction | Open |
| Subject Keyword | Allergy Il-5 Il-5rα Medi-563 Asthma Asthma Treatments Benralizumab Eosinophils |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pulmonary and Respiratory Medicine Immunology and Allergy |
