Loading...
Please wait, while we are loading the content...
Similar Documents
Current treatments and strategies for type 2 diabetes: Can we do better with GLP-1 receptor agonists?
| Content Provider | Scilit |
|---|---|
| Author | Peterson, Gregory |
| Copyright Year | 2011 |
| Description | Diet, lifestyle modification, and pharmacotherapy with metformin are appropriate initial treatments for many patients with type 2 diabetes (T2DM). However, most individuals do not maintain glycemic control with metformin alone. Addition of other oral antidiabetes drugs (OADs), including sulfonylurea, meglitinide, or thiazolidinedione, is often the next step. Newer options, including incretin-based glucagon-like peptide-1 (GLP-1) receptor agonists (RAs) and dipeptidyl peptidase-4 (DPP-4) inhibitors, offer important benefits as monotherapies or in combination with OADs, with low risk for hypoglycemia. Reductions in glycated hemoglobin (A1C) have been reported among patients treated with GLP-1 RAs (exenatide, −0.8 to −1.1%; liraglutide, −0.8 to −1.6%), as has weight loss (exenatide, −1.6 to −3.1 kg; liraglutide, −1.6 to −3.2 kg). GLP-1 RAs also stimulate β-cell responses and have positive effects on cardiovascular risk factors often present in patients with T2DM. The most common adverse events associated with GLP-1 RAs are nausea, which diminishes over time, and hypoglycemia (when used in combination with a sulfonylurea). A large number of trials demonstrated benefits of GLP-1 RAs, suggesting they could provide suitable treatment options for patients with T2DM. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.3109/07853890.2011.653392 |
| Ending Page | 349 |
| Page Count | 12 |
| Starting Page | 338 |
| ISSN | 07853890 |
| e-ISSN | 13652060 |
| DOI | 10.3109/07853890.2011.653392 |
| Journal | Annals of Medicine |
| Issue Number | 4 |
| Volume Number | 44 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2011-05-17 |
| Access Restriction | Open |
| Subject Keyword | Journal: Annals of Medicine Medical Laboratory Technology Exenatide Glucagon-like Peptide-1 Receptor Agonists Incretin-based Therapy Incretin Mimetics Liraglutide Type 2 Diabetes Mellitus |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine |
