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Surface Morphology Study of Solid Powders Evaluated by Particle Size Distribution and Nitrogen Adsorption
| Content Provider | Scilit |
|---|---|
| Author | Faroongsarng, Damrongsak Peck, Garnet E. |
| Copyright Year | 1994 |
| Description | The surface morphology of five tableting excipients including unmilled dicalcium phosphate dihydrate (Di-Tab), microcrystalline cellulose (Avicel PH102), corn starch, croscarmellose sodium (Ac-di-sol), and sodium starch glycolate (Primojel) was studied using laser scattering particle size analysis and nitrogen adsorption surface area analysis. The surface area of particles disregarding porosity was obtained from the particle size distribution and the total area was obtained from the B.E.T. treatment of nitrogen adsorption results. The so-called Surface Irregularity Index (SII) was established to indicate surface roughness due to porosity. The SII value was consistent with the microscopic visualization of a powder sample. Furthermore, the nitrogen adsorption-desorption isotherm hysteresis which showed the evidence of porosity was also consistent with the index. The SII may be an alternative way to characterize the surface morphology of a solid powder. |
| Related Links | http://www.tandfonline.com/doi/pdf/10.3109/03639049409042642 |
| Ending Page | 2367 |
| Page Count | 15 |
| Starting Page | 2353 |
| ISSN | 03639045 |
| e-ISSN | 15205762 |
| DOI | 10.3109/03639049409042642 |
| Journal | Drug Development and Industrial Pharmacy |
| Issue Number | 15 |
| Volume Number | 20 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 1994-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Drug Development and Industrial Pharmacy Characterization and Testing of Materials Surface Roughness Sodium Particle Size Starch Surface Morphology Solid Nitrogen Adsorption |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Drug Discovery Pharmacology Pharmaceutical Science |
