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The Relationship Between Clinical Trial Participation and Inhaler Technique Errors in Asthma and COPD Patients
| Content Provider | Scilit |
|---|---|
| Author | Perumal, Rubeshan Leite, Marcia van Zyl-Smit, Richard Nellis |
| Copyright Year | 2020 |
| Description | Background: Incorrect inhaler use is associated with poorer health outcomes, reduced quality of life, and higher healthcare utilisation in patients with asthma and COPD. Methods: We performed an observational study of pressurized metered-dose inhaler technique in patients with asthma or COPD. Patients were assessed using a six-point inhaler checklist to identify common critical inhaler technique errors. An inadequate inhaler technique was defined as the presence of one or more critical errors. A multivariate logistic regression model was used to determine the odds of an inadequate inhaler technique. Results: During the 14-month study period, 357 patients were enrolled. At least one critical error was executed by 66.7% of participants, and 24.9% made four or more critical errors. The most common errors were failure to exhale completely prior to pMDI activation and inhalation (49.6%), failure to perform a slow, deep inhalation following device activation (48.7%), and failure to perform a breath-hold at the end of inspiration (47.3%). The risk of a critical error was higher in COPD patients (aOR 2.25, 95% CI 1.13– 4.47). Prior training reduced error risk specifically when trained by a doctor (aOR 0.08, 95% CI 0.1– 0.57) or a pharmacist (aOR 0.02, 95% CI 0.01– 0.26) compared to those with no training. Previous clinical trial participation significantly reduced error risk and rate: < 3 trials (aOR 0.35, 95% CI 0.19– 0.66) and ≥ 3 trials (aOR 0.17, 95% CI 0.07– 0.42). The rate of critical errors was not significantly associated with age, sex, or prior pMDI experience. Conclusion: This study found a high rate of critical inhaler technique errors in a mixed population of asthma and COPD patients; however, prior training and, in particular, multiple previous clinical trial participation significantly reduced the risk of errors. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277230/pdf https://www.dovepress.com/getfile.php?fileID=58548 |
| Ending Page | 1224 |
| Page Count | 8 |
| Starting Page | 1217 |
| ISSN | 11769106 |
| e-ISSN | 11782005 |
| DOI | 10.2147/copd.s249620 |
| Journal | International journal of chronic obstructive pulmonary disease |
| Volume Number | 15 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2020-06-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: International Journal of Chronic Obstructive Pulmonary Disease Respiratory System Copd Asthma Clinical Trials Inhaler Pressurised Metered-dose Inhaler |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pulmonary and Respiratory Medicine Public Health, Environmental and Occupational Health Health Policy |
