NDLI: Transplantation of CD34+ Hematopoietic Progenitor Cells

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Transplantation of CD34+ Hematopoietic Progenitor Cells

Content Provider	Scilit
Author	Berenson, Ronald J. Shpall, Elizabeth J. Auditore-Hargreaves, Karen Heimfeld, Shelly Jacobs, Cindy Krieger, Monica S.
Copyright Year	1996
Description	We have developed an avidin-biotin immunoadsorption technique in conjunction with a monoclonal anti-CD34 antibody that is capable of selecting CD34+ progenitor cells from marrow and mobilized peripheral blood. Clinical studies with these CD34+ selected cells have shown that the cells are capable of rapid and durable engraftment. In addition, there is significantly less infusional toxicity to the patient because the volume in which the CD34+ selected cells are contained is much less than that of a typical marrow or apheresis buffy coat. Selection of CD34+ progenitor cells also offers other potential advantages, including T-cell depletion of allografts and tumor cell depletion of autografts. CD34+ selection can also be used to facilitate other manipulations of marrow and peripheral blood, including gene transfection, ex vivo stem cell expansion, tumor purging, and progenitor cell banking. Future graft engineering studies are expected to clarify these relationships and enable refinement of the graft to the point at which GVHD can be minimized, graft survival maximized, and relapse-free survival prolonged.
Related Links	http://www.tandfonline.com/doi/pdf/10.3109/07357909609076903
Ending Page	596
Page Count	8
Starting Page	589
ISSN	07357907
e-ISSN	15324192
DOI	10.3109/07357909609076903
Journal	Cancer Investigation
Issue Number	6
Volume Number	14
Language	English
Publisher	Informa UK Limited
Publisher Date	1996-01-01
Access Restriction	Open
Subject Keyword	Journal: Cancer Investigation Cell Tissue Engineering Antibody Survival Hematopoietic Graft Progenitor Cells Cd34 Cell Depletion
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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