Loading...
Please wait, while we are loading the content...
Similar Documents
Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for colorectal peritoneal carcinomatosis: higher complication rate for oxaliplatin compared to Mitomycin C.
| Content Provider | Scilit |
|---|---|
| Author | Rouers, A. Laurent, S. Detroz, B. Meurisse, M. |
| Copyright Year | 2006 |
| Description | Background : Peritoneal carcinomatosis (PC) from colo-rectal cancer carries a very poor prognosis with a mean and median overall survival times of 6.9 and 5.2 months. It has been proved that a locoregional therapeutic approach of this disease with cytoreduction followed by hyperthermic intraperitoneal chemotherapy (HIPEC) improved survival of these patients. However, this combined treatment presents a high complication rate. Methods : 21 patients with PC of colorectal origin underwent complete cytoreduction followed by HIPEC using Mitomycin-C (13 patients) or oxaliplatin (8 patients) and the open coliseum technique. For each case the medical datas were retrospectively analysed to determine feasibility, morbidity, mortality, survival time and prognostic factors. Results : All patients presented a Sugarbaker's Peritoneal Cancer index inferior to 15. The mean operating time was 453 minutes. After a median follow-up of 24.9 months, actuarial disease-free survival was 36.6% at 5 years. The median survival time was 34 months. The morbidity rate was 33.3% with a significant higher complication rate in the oxaliplatin group (5/8) than in the Mytomycin-C (MMC) group (2/13). One patient (4.7%) died two months after treatment with MMC (endocarditis). Conclusions : This series confirm positive impact of cytoreduction and HIPEC on PC. We obtained a moderated complications rate thanks to a high degree of selection of the patient. Oxaliplatin scheme is responsible of a higher morbidity than in MMC group. Phase III trial comparing these two drugs is needed. |
| Related Links | http://orbi.ulg.ac.be/bitstream/2268/81973/1/rouers%281%29.pdf |
| Ending Page | 306 |
| Page Count | 5 |
| Starting Page | 302 |
| ISSN | 00015458 |
| DOI | 10.1080/00015458.2006.11679897 |
| Journal | Acta chirurgica Belgica |
| Issue Number | 3 |
| Volume Number | 106 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2006-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Acta Chirurgica Belgica Gastroenterology and Hepatology Cytoreductive Surgery Hyperthermic Intraperitoneal Chemotherapy Peritoneal Carcinomatosis Colorectal Cancer Oxaliplatin Mitomycin C |
| Content Type | Text |
| Resource Type | Article |
| Subject | Surgery |
