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Reduced Vitamin D Levels are Associated with Stroke-Associated Pneumonia in Patients with Acute Ischemic Stroke
| Content Provider | Scilit |
|---|---|
| Author | Huang, Gui-Qian Cheng, Hao-Ran Wu, Yue-Min Cheng, Qian-Qian Wang, Yu-Min Fu, Jia-Li Zhou, Hui-Xin Wang, Zhen |
| Copyright Year | 2019 |
| Description | Background and aim: Stroke-associated pneumonia (SAP) is a common complication in patients with acute ischemic stroke (AIS). This study explored the potential relationship between serum vitamin D levels and SAP. Methods: This study recruited 863 consecutive AIS patients. In-hospital SAP was defined as a complication that occurred after stroke, during hospitalization, that was confirmed radiographically. Serum vitamin D levels were measured within 24 hrs of admission and the patients were divided into vitamin D sufficient (>50 nmol/L), insufficient (25–50 nmol/L), and deficient (Results: In this study, 102 (11.8%) patients were diagnosed with SAP. Compared to the patients without SAP, patients with SAP had significantly lower vitamin D levels (P = 0.023). The incidence of SAP was significantly higher in patients with vitamin D deficiency than in those with vitamin D insufficiency or sufficiency (21.2% vs 16.2% & 9.5%, P = 0.006). After adjusting for confounders, vitamin D deficiency and insufficiency were independently associated with SAP (OR = 3.034, 95% CI = 1.207–7.625, P = 0.018; OR = 1.921, 95% CI = 1.204–3.066, P = 0.006, respectively). In multiple-adjusted spline regression, vitamin D levels showed a linear association with the risk of SAP (P < 0.001 for linearity). Conclusion: Reduced vitamin D is a potential risk factor of in-hospital SAP, which can help clinicians identify high-risk SAP patients. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6946633/pdf https://www.dovepress.com/getfile.php?fileID=55078 |
| Ending Page | 2314 |
| Page Count | 10 |
| Starting Page | 2305 |
| ISSN | 11769092 |
| e-ISSN | 11781998 |
| DOI | 10.2147/cia.s230255 |
| Journal | Clinical interventions in aging |
| Volume Number | 14 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2019-12-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Clinical Interventions in Aging Peripheral Vascular Disease Acute Ischemic Stroke Stroke-associated Pneumonia Vitamin D |
| Content Type | Text |
| Resource Type | Article |
| Subject | Geriatrics and Gerontology |
