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Acetylcholine Controls the Gain of the Voltage-to-Movement Converter in Isolated Outer Hair Cells
| Content Provider | Scilit |
|---|---|
| Author | Sziklai, Istvan Dallos, Peter |
| Copyright Year | 1993 |
| Description | Sensitivity of the electromotility of isolated guinea pig outer hair cells (OHCs) to acetylcholine (ACh) was examined. OHCs were held in a partitioning microchamber in a position so that their ciliary poles were inserted and their somatic length changes measured. Transcellular square-wave stimuli were delivered to record voltage-to-movement conversion of the cells. ACh was applied to the synaptic poles. The transfer function of electromotility intimated shifts of the membrane potential with concomitant gain changes: gain decreases when the membrane potential is shifted in hyperpolarization direction and gain increases when the membrane potential is shifted in the opposite direction due to application of ACh in 100-500/JM concentration. Clear gain increase of the electromotility in basal turn OHCs to ACh was observed, whereas inconsistent results for apical turn OHCs were found. The latter is probably due to the pharmacological dose of ACh used. This possibility is further supported by results in which ACh abolished the sensitivity of the magnitude response of electromotility to DC depolarizing bias. |
| Related Links | http://www.tandfonline.com/doi/pdf/10.3109/00016489309135818 |
| Ending Page | 329 |
| Page Count | 4 |
| Starting Page | 326 |
| ISSN | 00016489 |
| e-ISSN | 16512251 |
| DOI | 10.3109/00016489309135818 |
| Journal | Acta Oto-Laryngologica |
| Issue Number | 3 |
| Volume Number | 113 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 1993-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Acta Oto-laryngologica Dentistry and Oral Surgery Hair Cells Controls the Gain Acetylcholine Controls Isolated Outer Outer Hair Converter Voltage |
| Content Type | Text |
| Resource Type | Article |
| Subject | Otorhinolaryngology |
