NDLI: Combination of Fludarabine and Imatinib Induces Apoptosis Synergistically Through Loss of Mitochondrial Membrane Potential and Increases in Caspase-3 Enzyme Activity in Human K562 Chronic Myleloid Leukemia Cells

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Combination of Fludarabine and Imatinib Induces Apoptosis Synergistically Through Loss of Mitochondrial Membrane Potential and Increases in Caspase-3 Enzyme Activity in Human K562 Chronic Myleloid Leukemia Cells

Content Provider	Scilit
Author	Baran, Yusuf Oztekin, Coskun Bassoy, Esen Yonca
Copyright Year	2009
Description	In this study, we aimed to show the synergistic apoptotic effects of imatinib/fludarabine combination in human K562 chronic myleloid leukemia (CML) cells. There was a significant increase in cytotoxicity of combination of imatinib and fludarabine as compared to any agent alone. On the other hand, combination of both agents induced apoptosis significantly as confirmed by increases in caspase-3 enzyme activity and decreases in mitochondrial membrane potential. As a summary, the results of this study strongly suggest that combination of imatinib and fludarabine induced cell death synergistically comparing to only imatinib or fludarabine in human K562 CML cells. Copyright © 2010 Informa Healthcare USA, Inc
Related Links	https://core.ac.uk/download/pdf/83047314.pdf http://openaccess.iyte.edu.tr/bitstream/11147/2726/1/2726.pdf
Ending Page	628
Page Count	6
Starting Page	623
ISSN	07357907
e-ISSN	15324192
DOI	10.3109/07357901003631056
Journal	Cancer Investigation
Issue Number	6
Volume Number	28
Language	English
Publisher	Informa UK Limited
Publisher Date	2009-11-02
Access Restriction	Open
Subject Keyword	Journal: Cancer Investigation Cell Tissue Engineering Pathology Apoptosis Enzyme Cytotoxicity Imatinib and Fludarabine Human K562 Activity IN Human Myleloid
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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