NDLI: Rapid Diagnosis of Trisomy 18 and Dizygosity in Twins Using Fluorescence in Situ Hybridization on Uncultured Amniocytes

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Rapid Diagnosis of Trisomy 18 and Dizygosity in Twins Using Fluorescence in Situ Hybridization on Uncultured Amniocytes

Content Provider	Scilit
Author	Blakemore, Karin J. Rosenberg, Carla Jaswaney, Vikram L. Pressman, Eva K. Kearns, William G. Pearson, Peter L. Stetten, Gail
Copyright Year	1993
Description	Background: The diagnosis of a chromosomally abnormal third trimester fetus prior to birth permits optimal obstetrical management and psychological support for the parents when the child is born. Although ultrasound findings may lead to suspicion of Edward syndrome, confirmation of the diagnosis depends on the cytogenetic detection of trisomy 18. Certain obstetrical situations may limit the choice of diagnostic procedures to amniocentesis when a rapid cytogenetic result in required. Case: Fluorescence in situ hybridization in uncultured amniocytes permitted rapid detection of trisomy 18 in one twin following preterm labor, allowing a definitive diagnosis before birth. Conclusion: The technique described enables a rapid, targeted cytogenetic result using uncultured amniocytes. This is a valuable new tool when a specific fetal aneuploidy is strongly suggested by sonography and obstetrical factors preclude the use of procedures other than amniocentesis.
Related Links	https://www.tandfonline.com/doi/pdf/10.3109/14767059309017341
Ending Page	200
Page Count	4
Starting Page	197
ISSN	14767058
e-ISSN	14764954
DOI	10.3109/14767059309017341
Journal	The Journal of Maternal-Fetal & Neonatal Medicine
Issue Number	4
Volume Number	2
Language	English
Publisher	Informa UK Limited
Publisher Date	1993-01-01
Access Restriction	Open
Subject Keyword	Journal: The Journal of Maternal-fetal & Neonatal Medicine Womens Studies Prenatal Diagnosis Cytogenetics Trisomy 18 Fluorescence in Situ Hybridization Uncultured Amniocytes
Content Type	Text
Resource Type	Article
Subject	Pediatrics, Perinatology and Child Health Obstetrics and Gynecology

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