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Neuropilin, you gotta let me know
| Content Provider | Scilit |
|---|---|
| Author | Schwarz, Quenten Ruhrberg, Christiana |
| Copyright Year | 2010 |
| Description | Neuropilins are highly conserved single pass transmembrane proteins specific to vertebrates. They were originally identified as adhesion molecules in the nervous system, but were subsequently rediscovered as the ligand binding subunit of the class 3 semaphorin receptor in neurons and then as blood vessel receptors for the vascular endothelial growth factor VEGF. More recently they have also been implicated as mediators of the T-cell immune response and as key prognostic markers in several types of cancer. Because neuropilins bind multiple ligands and associate with several different types of co-receptors, they variably promote cell adhesion, repulsion or attraction. Which response they ultimately invoke is decided by the cellular and even subcellular context the neuropilins find themselves in. Here, we review how the developmental functions of the neuropilins are influenced by such different contexts. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.4161/cam.4.1.10207?needAccess=true https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852559/pdf |
| Ending Page | 66 |
| Page Count | 6 |
| Starting Page | 61 |
| ISSN | 19336918 |
| e-ISSN | 19336926 |
| DOI | 10.4161/cam.4.1.10207 |
| Journal | Cell adhesion & migration |
| Issue Number | 1 |
| Volume Number | 4 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2010-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Cell Adhesion & Migration Cell Biology Neuropilin Semaphorin Vegf Plexin Neuron Endothelial Cell Blood Vessel Angiogenesis Cell Migration |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Cellular and Molecular Neuroscience |
