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Germline minisatellite mutations in survivors of childhood and young adult cancer treated with radiation
| Content Provider | Scilit |
|---|---|
| Author | Tawn, E. Janet Rees, Gwen S. Leith, Cheryl Winther, Jeanette F. Curwen, Gillian B. Stovall, Marilyn Olsen, Jørgen Helge Rechnitzer, Catherine Schroeder, Henrik Guldberg, Per Boice, John D. |
| Copyright Year | 2010 |
| Description | Purpose: To investigate minisatellite germline mutation rates in survivors of childhood and young adult cancer who received radiotherapy. Materials and methods: DNA samples from 100 families, where one parent was a cancer survivor, were analysed for mutations at eight hypervariable minisatellite loci (B6.7, CEB1, CEB15, CEB25, CEB36, MS1, MS31, MS32) by Southern hybridisation. Results: No significant difference was observed between the paternal mutation rate of 5.6% in exposed fathers with a mean preconceptional testicular dose of 1.23 Gy (56 mutations in 998 informative alleles) and that of 5.8% in unexposed fathers (17 in 295 informative alleles). Subgrouping the exposed fathers into dose groups of <0.10 Gy, 0.10–0.99 Gy, 1.00–1.99 Gy, ≥2.00 Gy revealed no significant differences in paternal mutation rate in comparison with the unexposed fathers. Maternal mutation rates of 1.6% in cancer survivor mothers with a mean preconceptional ovarian dose of 0.58 Gy (five mutations in 304 informative alleles) and 2.1% in unexposed mothers (21 in 987 informative alleles) were not significantly different. There were no differences in minisatellite mutation rates associated with treatment with chemotherapeutic agents. Conclusions: This study provides evidence that preconception radiotherapy for childhood or early adulthood cancer does not increase the germline minisatellite mutation rate. |
| Related Links | http://europepmc.org/articles/pmc3766628?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766628/pdf https://www.tandfonline.com/doi/pdf/10.3109/09553002.2011.530338 |
| Ending Page | 340 |
| Page Count | 11 |
| Starting Page | 330 |
| ISSN | 09553002 |
| e-ISSN | 13623095 |
| DOI | 10.3109/09553002.2011.530338 |
| Journal | International Journal of Radiation Biology |
| Issue Number | 3 |
| Volume Number | 87 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2010-11-19 |
| Access Restriction | Open |
| Subject Keyword | Journal: International Journal of Radiation Biology Oncology Minisatellite Germline Mutation Ionising Radiation Childhood and Young Adult Cancer |
| Content Type | Text |
| Resource Type | Article |
| Subject | Radiology, Nuclear Medicine and Imaging Radiological and Ultrasound Technology |
