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Susceptibility testing ofCryptococcus diffluensagainst amphotericin B, flucytosine, fluconazole, itraconazole, voriconazole and posaconazole
| Content Provider | Scilit |
|---|---|
| Author | Kantarcioğlu, A. Serda Boekhout, Teun Yücel, Ayhan Altas, Kemal |
| Copyright Year | 2009 |
| Description | Cryptococcus diffluens is a recently re-established species that shares several phenotypic features with Cryptococcus neoformans. We evaluated the application of the Clinical Laboratory Standards Institute (CLSI, formerly NCCLS) macro- and microbroth dilution methods and the E-test agar diffusion method to determine the in vitro susceptibilities of known strains of C. diffluens against amphotericin B (AMB), flucytosine (5-FC), fluconazole (FLC), itraconazole (ITC) and the novel triazoles, voriconazole (VRC) and posaconazole (PSC). Seven strains were found to be resistant in vitro to AMB (MICs ≥2µg/ml), five were resistant to 5-FC (MICs of ≥32 µg/ml), four were resistant to FLC (MICs of FLC ≥32µg/ml) and nine were resistant to ITC (MICs of ITC >1 µg/ml). In contrast, VRC and PSC showed good in vitro activity against C.diffluens strains, even those with elevated MICs to amphotericin B and/or established azoles. Most of the isolates were inhibited by 0.5µg/ml of both VRC and PSC. A clinical isolate showing phenotypic switching exhibited elevated MICs to both agents, i.e., VRC (>16µg/ml) and PSC (>8µg/ml). |
| Related Links | https://academic.oup.com/mmy/article-pdf/47/2/169/3859695/47-2-169.pdf |
| Ending Page | 176 |
| Page Count | 8 |
| Starting Page | 169 |
| ISSN | 13693786 |
| DOI | 10.1080/13693780802213407 |
| Journal | Medical mycology |
| Issue Number | 2 |
| Volume Number | 47 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2009-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Medical Mycology Mycology Diffusion Flucytosine Agar Amphotericin B Fluconazole Itraconazole Voriconazole Posaconazole E Test Dilution Technique Dilute (action) Isolated Tumor Cells Free Immunoglobulin Light Chain Malnutrition-inflammation-cachexia Syndrome Ixmyelocel-t Cryptococcus Phenotype Azoles Triazoles Cryptococcus Neoformans |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Veterinary |
