NDLI: TRAIL induces endocytosis of its death receptors in MDA-MB-231 breast cancer cells

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TRAIL induces endocytosis of its death receptors in MDA-MB-231 breast cancer cells

Content Provider	Scilit
Author	Zhang, Yaqin Yoshida, Tatsushi Zhang, Baolin
Copyright Year	2009
Description	TNF-related apoptosis-inducing ligand (TRAIL) is a promising anticancer agent that selectively induces apoptosis in cancer cells over normal cells. Here, we show that TRAIL undergoes rapid endocytosis with its death receptors DR4, and likely DR5, in MDA-MB-231 human breast cancer cells. The internalized DR4, but not DR5, is cleaved in a caspase-dependent manner. Blockade of receptor internalization does not prevent caspase activation, but rather enhances apoptosis after TRAIL treatment. TRAIL-induced receptor endocytosis appears to undermine its ability in inducing apoptosis.
Related Links	https://www.tandfonline.com/doi/pdf/10.4161/cbt.8.10.8141?needAccess=true
Ending Page	922
Page Count	6
Starting Page	917
ISSN	15384047
e-ISSN	15558576
DOI	10.4161/cbt.8.10.8141
Journal	Cancer Biology & Therapy
Issue Number	10
Volume Number	8
Language	English
Publisher	Informa UK Limited
Publisher Date	2009-05-15
Access Restriction	Open
Subject Keyword	Journal: Cancer Biology & Therapy Biochemistry and Molecular Biology Apoptosis Endocytosis Trail Induces Death Receptors Breast Cancer Mda Mb Dr5 Dr4 Cancer Cells
Content Type	Text
Resource Type	Article
Subject	Cancer Research Pharmacology Molecular Medicine Oncology

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