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Condensin Function in Mitotic Nucleolar Segregation is Regulated by rDNA Transcription
| Content Provider | Scilit |
|---|---|
| Author | Wang, Bi-Dar Butylin, Pavel Strunnikov, Alexander |
| Copyright Year | 2006 |
| Description | Chromosome condensation is established and maintained by the condensin complex. The mechanisms governing loading of condensin onto specific chromosomal sites remain unknown. To elucidate the molecular pathways that determine condensin binding to the nucleolar organizer, a key condensin binding site, we analyzed the properties of condensin-bound sites within the rDNA repeat in budding yeast and demonstrated that the bulk of mitotic condensin binding to rDNA is reduced or eliminated when Pol I transcription is elevated. Conversely, when Pol I transcription is repressed either by rapamycin treatment or by promoter shut-off, condensin binding to rDNA is increased. This novel potential role for constitutive and/or periodic repression of Pol I transcription in rDNA condensin loading is an important factor in determining the segregation proficiency of NOR-containing chromosomes. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3225123/pdf |
| Ending Page | 2267 |
| Page Count | 8 |
| Starting Page | 2260 |
| ISSN | 15384101 |
| e-ISSN | 15514005 |
| DOI | 10.4161/cc.5.19.3292 |
| Journal | Cell Cycle |
| Issue Number | 19 |
| Volume Number | 5 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2006-09-12 |
| Access Restriction | Open |
| Subject Keyword | Journal: Cell Cycle Cell Biology Condensin Nucleolus Transcription Chromosome Segregation Chromosome Condensation Rfb Fob1 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Developmental Biology Medicine Molecular Biology |
