NDLI: Clonality Switch in Acute Myeloid Leukemia

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Clonality Switch in Acute Myeloid Leukemia

Content Provider	Scilit
Author	Yin, John A. Liu Jowitt, Simon N.
Copyright Year	1996
Description	We have previously described a case of clonality switch in a female patient with acute myeloid leukemia (AML) by X-chromosome inactivation analysis. She presented with refractory anemia with excess blasts in transformation but soon progressed to overt AML. Following induction chemotherapy, she went into complete remission but later relapsed into a second myelodysplastic phase. Analysis of her X-linked DNA polymorphism patterns at presentation and relapse showed that hematopoiesis was clonal, but the genotypes of the two clones was different. She remains clinically well and has a virtually normal blood count more than 5 years from presentation. We now report an update of this unique case and discuss the implications of this finding within the context of a multicellular origin of leukemia.
Related Links	http://www.tandfonline.com/doi/pdf/10.3109/10428199609051739
Ending Page	130
Page Count	6
Starting Page	125
ISSN	10428194
e-ISSN	10292403
DOI	10.3109/10428199609051739
Journal	Leukemia & Lymphoma
Issue Number	1
Volume Number	22
Language	English
Publisher	Informa UK Limited
Publisher Date	1996-01-01
Access Restriction	Open
Subject Keyword	Journal: Leukemia & Lymphoma Oncology Acute Myeloid Leukemia Anemia Aml Polymorphism Clonality Switch Blood Count X Chromosome Inactivation Relapse
Content Type	Text
Resource Type	Article
Subject	Hematology Cancer Research Oncology

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