NDLI: HSP27 and HSP70: potentially oncogenic apoptosis inhibitors.

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HSP27 and HSP70: potentially oncogenic apoptosis inhibitors.

Content Provider	Scilit
Author	Garrido, Carmen Schmitt, Elise Candé, Céline Vahsen, Nicola Parcellier, Arnaud Kroemer, Guido
Copyright Year	2003
Description	Stress or heat shock proteins (HSPs) such as HSP27 and HSP70 are expressed in response to a wide variety of physiological and environmental insults including heat, reactive oxygen species or anticancer drugs. Their overexpression allows cells to survive to otherwise lethal conditions. Several different mechanisms may account for the cytoprotective activity of HSP27 and HSP70. First, both proteins are powerful chaperones. Second, both inhibit key effectors of the apoptotic machinery including the apoptosome, the caspase activation complex (both HSP27 and HSP70), and apoptosis inducing factor (only HSP70). Third, they both play a role in the proteasome-mediated degradation of apoptosis-regulatory proteins. HSP27 and HSP70 may participate in oncogenesis, as suggested by the fact that overexpression of heat shock proteins can increase the tumorigenic potential of tumor cells. The down-regulation or selective inhibition of HSP70 might constitute a valuable strategy for the treatment of cancer.
Related Links	http://www.tandfonline.com/doi/pdf/10.4161/cc.2.6.521?needAccess=true https://www.landesbioscience.com/journals/cc/garridoCC2-6.pdf
Ending Page	583
Page Count	6
Starting Page	578
ISSN	15384101
e-ISSN	15514005
DOI	10.4161/cc.2.6.521
Journal	Cell Cycle
Issue Number	6
Volume Number	2
Language	English
Publisher	Informa UK Limited
Publisher Date	2003-11-28
Access Restriction	Open
Subject Keyword	Journal: Cell Cycle Biochemistry and Molecular Biology Stress Apoptosis Heat Shock Hsp70 Hsp27 Survive Shock Proteins Streß
Content Type	Text
Resource Type	Article
Subject	Cell Biology Developmental Biology Medicine Molecular Biology

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