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Efficacy and safety of sustained-delivery fluocinolone acetonide intravitreal implant in patients with chronic diabetic macular edema insufficiently responsive to available therapies: a real-life study
| Content Provider | Scilit |
|---|---|
| Author | Massin, Pascale Erginay, Ali Dupas, Bénédicte Couturier, Aude Tadayoni, Ramin |
| Copyright Year | 2016 |
| Description | Efficacy and safety of sustained-delivery fluocinolone acetonide intravitreal implant in patients with chronic diabetic macular edema insufficiently responsive to available therapies: a real-life study Pascale Massin, Ali Erginay, Bénédicte Dupas, Aude Couturier, Ramin Tadayoni Ophthalmology Department, Lariboisière Hospital, Paris, France Purpose: To evaluate the efficacy and safety of sustained-delivery fluocinolone acetonide (FAc) intravitreal implant for diabetic macular edema (DME). Patients and methods: Prospective study in patients with DME insufficiently responsive to laser and anti-vascular endothelial growth factor (anti-VEGF). Patients with history of rise of intraocular pressure after intravitreal corticosteroids were excluded. Results: The macular edema rapidly decreased both in group 1 (prior laser only; n=7 eyes) and group 2 (prior laser and ≥3 monthly anti-VEGF therapy; n=10 eyes) and central subfield thickness was reduced by -299 µm (P=0.008) and -251 µm (P=0.016) at 12 months, respectively. Mean area under the curve from baseline to last value for pseudophakic eyes was +4.2 letters in group 1 and +9.5 letters in group 2. Overall, the FAc implant was well tolerated. Conclusion: This prospective study confirms the efficacy of the FAc implant in DME patients insufficiently responsive to laser and anti-VEGF. Moreover, with a careful patient selection, our safety results would support an earlier use of FAc in the DME treatment pathway. Keywords: diabetic macular edema, intravitreal corticosteroid, corticosteroid intravitreal implant, fluocinolone acetonide |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944911/pdf https://www.dovepress.com/getfile.php?fileID=31273 |
| Ending Page | 1264 |
| Page Count | 8 |
| Starting Page | 1257 |
| ISSN | 11775467 |
| e-ISSN | 11775483 |
| DOI | 10.2147/opth.s105385 |
| Journal | Clinical Ophthalmology |
| Volume Number | 10 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2016-07-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Clinical Ophthalmology Rehabilitation Corticosteroid Intravitreal Implant Diabetic Macular Edema Fluocinolone Acetonide Intravitreal Corticosteroid |
| Content Type | Text |
| Resource Type | Article |
| Subject | Ophthalmology |
