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Electrophysiological and psychophysical examination in patients with optic nerve compression
| Content Provider | Scilit |
|---|---|
| Author | Sadowski, Bettina Altenmüller, Eckart Zrenner, Eberhart |
| Copyright Year | 1995 |
| Description | Compression of the optic nerve causes a descending degeneration of optic nerve fibers. Additionally to the clinical symptoms (loss of visual acuity, scotomas), electrophysiological methods can be used to evaluate the function of the optic nerve (VEP) and the retinal ganglion cell layer (pattern ERG, PERG). In order to investigate the prognostic significance of electrophysiological methods for postoperative recovery of visual function, 11 patients (22 eyes) suffering from compression of the optic nerve or chiasm due to pituitary tumors or meningiomas were investigated prior to and after surgical decompression. Visual acuity and perimetry were compared to preoperatively performed transient pattern VEP and transient PERG (N-95 amplitude). Prior to surgery, the patients suffered from impairment of visual acuity and scotomas. After surgical decompression, visual acuity improved in seven eyes, remained unchanged in 11 eyes and deteriorated in four eyes. Visual field defects improved in 13 eyes, one visual field deteriorated. In all patients preoperative VEP examination revealed pathological findings (half and Ganzfeld). Latency of half field VEPs was prolonged in five eyes in which the corresponding visual fields were normal. The N95 of the PERG was also pathological in three eyes, which postoperatively did not reveal any improvement in visual fields. The results demonstrate that VEP latency can be more sensitive than the PERG in the diagnosis of compression with subsequent descending degeneration of the optic nerve. Pathological latencies when stimulating with half field VEPs can indicate a first subclinical damage of the optic nerve prior to psychophysical and morphological findings. Pathological PERGs prior to decompression seem to indicate a poor prognosis concerning the improvement of psychophysical function after surgery. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.3109/01658109509044606 |
| Ending Page | 231 |
| Page Count | 9 |
| Starting Page | 223 |
| ISSN | 01658107 |
| e-ISSN | 1744506X |
| DOI | 10.3109/01658109509044606 |
| Journal | Neuro-Ophthalmology |
| Issue Number | 5 |
| Volume Number | 15 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 1995-10-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Neuro-ophthalmology Neuroimaging Optic Nerve Pattern Electroretinogram (perg) Visual Evoked Potentials (vep) |
| Content Type | Text |
| Resource Type | Article |
| Subject | Ophthalmology Neurology (clinical) |
