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In Vitro Release of Amoxycillin from Lipophilic Suppositories
| Content Provider | Scilit |
|---|---|
| Author | Webster, J. A. Dowse, Ros Walker, R. B. |
| Copyright Year | 1998 |
| Description | The in vitro release characteristics of amoxycillin from different lipophilic suppository bases were investigated using the USP rotating basket method. Suppositories containing 250 mg amoxycillin were prepared in theobroma oil and in the semi-synthetic bases Witepsol W35, Suppocire A32, Novata BD, and Novata 299. Both freshly prepared and 1-month-old suppositories were tested. Analysis of amoxycillin was performed using a validated high-performance liquid chromatographic (HPLC) technique. Release profiles differed significantly between bases, with the greatest amount of amoxycillin being released from both newly made and 1-month-old Novata BD bases (87.57 +/- 8.18 and 99.66 +/- 6.63%, respectively), and the lowest amount released from the newly manufactured theobroma suppositories (8.82 +/- 0.75%) and the 1-month-old Suppocire A32 suppositories (7.78 +/- 0.27%). |
| Related Links | http://www.tandfonline.com/doi/pdf/10.3109/03639049809085636 |
| Ending Page | 399 |
| Page Count | 5 |
| Starting Page | 395 |
| ISSN | 03639045 |
| e-ISSN | 15205762 |
| DOI | 10.3109/03639049809085636 |
| Journal | Drug Development and Industrial Pharmacy |
| Issue Number | 4 |
| Volume Number | 24 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 1998-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Drug Development and Industrial Pharmacy Pharmacology and Pharmacy Suppositories Lipophilic Suppository Vitro Release Amoxycillin Being Released A32 Suppocire Theobroma Novata Bd |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Drug Discovery Pharmacology Pharmaceutical Science |
