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Folate Receptor-Targeted Liposomes
Content Provider | Scilit |
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Author | Pan, Xiaogang Lee, Robert J. Shivakumar, Srikanth |
Copyright Year | 2006 |
Description | Tumor cell selective targeting is an attractive approach to enhance the efficacy and therapeutic index of anticancer drugs. Targeted liposomal delivery is accomplished by attaching to the surface of drug-carrying liposomes a tumor cell-specific ligand via a lipophilic anchor. Folate receptor (FR) has been identified as a broad-spectrum tumor cell-surface marker. Lipophilic derivatives of folate, a high-affinity ligand for the FR, can be incorporated into liposomes for targeting tumor cells with amplified FR expression. This chapter will provide a brief overview of recent progress on FR-targeted liposomes, possible mechanisms for in vivo tumor targeting, and future directions. Book Name: Liposome Technology |
Related Links | https://content.taylorfrancis.com/books/download?dac=C2010-0-33224-1&isbn=9780429136009&doi=10.1201/9780849397288-14&format=pdf |
Ending Page | 216 |
Page Count | 20 |
Starting Page | 197 |
DOI | 10.1201/9780849397288-14 |
Language | English |
Publisher | Informa UK Limited |
Publisher Date | 2006-09-12 |
Access Restriction | Open |
Subject Keyword | Book Name: Liposome Technology Biomedical Engineering Receptor Folate Lipophilic Targeted Liposomes Tumor Cell Liposomes for Targeting Tumor |
Content Type | Text |
Resource Type | Chapter |