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Immunological and histological evaluation of clinical samples from psoriasis patients treated with anti-CD6 itolizumab
| Content Provider | Scilit |
|---|---|
| Author | Aira, Lazaro E. López-Requena, Alejandro Fuentes, Dasha Sánchez, Liset Perez, Teresita Urquiza, Aleida Bautista, Heber Falcon, Leopoldina Hernandez, Patricia Mazorra, Zaima |
| Copyright Year | 2014 |
| Description | Psoriasis is a chronic inflammatory disease with a prevalence of approximately 2–3% in the general population. The majority of diagnosed patients have plaque psoriasis, and about 20% have moderate-to-severe disease. Itolizumab, a new monoclonal antibody specific for the CD6 molecule mainly expressed on T lymphocytes, has demonstrated to inhibit in vitro ligand-induced proliferation and pro-inflammatory cytokine production. We assessed the immunological and histopathological effect of the antibody using clinical samples taken from 26 patients with moderate-to-severe psoriasis included in a clinical trial. The precursor frequency of lymphocytes activated with anti-CD2/CD3/CD28 beads, as well as the number of interferon (IFN)-γ-secreting T cells after stimulation, were measured at different time points of the study. Serum cytokine levels and anti-idiotypic antibody response to itolizumab were also evaluated. Additionally, lymphocyte infiltration and epidermis hyperplasia were studied in five patients. A significant reduction in T cell proliferation capacity and number of IFN-γ-producing T cells was found in treated patients. Serum levels of interleukin-6, tumor necrosis factor and IFN-γ showed an overall trend toward reduction. No anti-idiotypic antibody response was detected. A significant reduction in the epidermis hyperplasia was observed in analyzed patients. These results support the relevance of the CD6 molecule as a therapeutic target for the treatment of this disease. |
| Related Links | http://www.tandfonline.com/doi/pdf/10.4161/mabs.28376?needAccess=true https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011922/pdf |
| Ending Page | 792 |
| Page Count | 11 |
| Starting Page | 782 |
| ISSN | 19420862 |
| e-ISSN | 19420870 |
| DOI | 10.4161/mabs.28376 |
| Journal | mAbs |
| Issue Number | 3 |
| Volume Number | 6 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2014-03-03 |
| Access Restriction | Open |
| Subject Keyword | Journal: Mabs Dermatology Cd6 Anti-idiotypic Antibody Response Cell Proliferation Epidermal Hyperplasia Itolizumab Pro-inflammatory Cytokines Psoriasis |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
