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Animal Models for the Study of Bacterial Biofilms
| Content Provider | Scilit |
|---|---|
| Author | Evans, L. V. |
| Copyright Year | 2000 |
| Description | Animal models are an integral component of biomedical research in general, and their use in the study of bacterial biofilms is of central importance. The significance of infections associated with bacterial biofilms on medical devices and within tissue has been recognised over the past two decades. Device-associated infections are some of the most common types of bacterial infection and are the most difficult to treat (Vaudaux et al., 1994). Such infections are usually initiated by autochthonous microorganisms from the skin (Staphylococcus aureus, Staphylococcus epidermidis), the bowel (Escherichia coli) or the environment (Pseudomonas aeruginosa). When otherwise not associated with an implant, such organisms are usually readily eliminated by host defences or chemotherapeutic agents. It has been shown in clinical disease and in animal models that implantation of a foreign body increases the susceptibility to bacterial infection (Vaudaux et al., 1994). Animal models have improved understanding of complex interactions between adherent bacteria on a medical device and the surrounding tissue. In turn, this will help develop therapeutic agents and/or medical devices less prone to infections. Implant infections frequently result when bacteria become protected from host elimination through association with the implant. A true representation of such associations can only be studied by using animal models. Ultimately, the information gained in studies employing animal models will help establish a rational basis for initiation of human clinical trials. This chapter is not an all-inclusive survey of animal models for biofilm infections, but discusses effective and commonly used models that have provided valuable information regarding the pathogenesis and treatment of tissue and device-associated infections. Book Name: Biofilms |
| Related Links | https://content.taylorfrancis.com/books/download?dac=C2004-0-24134-2&isbn=9780429078743&doi=10.1201/9781482284157-15&format=pdf |
| Ending Page | 168 |
| Page Count | 16 |
| Starting Page | 153 |
| DOI | 10.1201/9781482284157-15 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2000-12-21 |
| Access Restriction | Open |
| Subject Keyword | Book Name: Biofilms Biomedical Engineering Bacterial Infection Device Associated Infections Biofilms Animal Models Eliminated By Host |
| Content Type | Text |
| Resource Type | Chapter |
