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Simultaneous Determination of Pseudoephidrine HC1 (PSE) and Terfanidine (TER) from Formulations by Reversed-Phase Ion Pair High-Performance Liquid Chromatography (RP-HPLC)
| Content Provider | Scilit |
|---|---|
| Author | Argekar, A. P. Shah, S. J. Raj, S. V. |
| Copyright Year | 1998 |
| Description | A new simple, precise, rapid, and selective reversed-phase ion pair high-performance liquid chromatography (RP-HPLC) method has been developed for the simultaneous determination of pseudoephidrine (PSE) and terfanidine (TER) from tablets using 60:15:25 acetontrile:methanol:water (v/v) containing 2.9 g sodium lauryl sulfate/liter, pH adjusted to 3.1 using phosphoric acid as a mobile phase and C18 Spherisorb ODS 2 (3 microns, 5 cm x 4.6 mm i.d.) as stationary phase. Detection was carried out using a UV detector at 254 nm. A constant flow of 1.0 ml/min was maintained throughout the analysis. Retention times for PSE and TER were 1.90 and 7.35 min, respectively. Linearity range and percentage recoveries for PSE and TER were 24-1200 and 12-600 micrograms/ml, and 100.01 and 100.4%, respectively. |
| Related Links | http://www.tandfonline.com/doi/pdf/10.3109/03639049809085613 |
| Ending Page | 223 |
| Page Count | 5 |
| Starting Page | 219 |
| ISSN | 03639045 |
| e-ISSN | 15205762 |
| DOI | 10.3109/03639049809085613 |
| Journal | Drug Development and Industrial Pharmacy |
| Issue Number | 3 |
| Volume Number | 24 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 1998-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Drug Development and Industrial Pharmacy Legal Medicine High Performance Liquid Chromatography Terfanidine Pseudoephidrine Stationary Phase Phase Ion Simultaneous Determination Reversed Phase Rp Hplc |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Drug Discovery Pharmacology Pharmaceutical Science |
