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An improved synthesis of 'octa-acid' deep-cavity cavitand
| Content Provider | Scilit |
|---|---|
| Author | Liu, Simin Whisenhunt-Ioup, Sarah E. Gibb, Corinne L. D. Gibb, Bruce C. |
| Copyright Year | 2011 |
| Description | An improved synthesis of a water-soluble deep-cavity cavitand (octa-acid, 1) is presented. Previously (Gibb, C.L.D.; Gibb, B.C. J. Am. Chem. Soc. 2004, 126, 11408–11409), we documented access to host 1 in eight (non-linear) steps starting from resorcinol; a synthesis that required four steps involving chromatographic purification. Here, we reveal a modified synthesis of host 1. Consisting of seven (non-linear) steps, this new synthesis involves only one chromatographic step, and avoids a minor impurity observed in the original approach. This improved synthesis is therefore useful for the laboratories that are investigating the properties of these types of host. |
| Related Links | http://europepmc.org/articles/pmc3110010?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110010/pdf |
| Ending Page | 485 |
| Page Count | 6 |
| Starting Page | 480 |
| ISSN | 10610278 |
| e-ISSN | 10290478 |
| DOI | 10.1080/10610278.2010.550290 |
| Journal | Supramolecular Chemistry |
| Issue Number | 6 |
| Volume Number | 23 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2011-04-15 |
| Access Restriction | Open |
| Subject Keyword | Journal: Supramolecular Chemistry Medicinal Chemistry Organic Chemistry Host Cavitand Water-soluble Octa-acid Supramolecular Chemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry |
