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TNF-α (−308) Gene Polymorphism and Type 2 Diabetes Mellitus in Ethiopian Diabetes Patients
| Content Provider | Scilit |
|---|---|
| Author | Ayelign, Birhanu Genetu, Meaza Wondmagegn, Tadelo Adane, Gashaw Negash, Markos Berhane, Nega |
| Copyright Year | 2019 |
| Description | Background: Type 2 diabetes mellitus (T2DM) is a metabolic disorder resulting from insulin insufficiency or function. Predisposing factors for T2DM are mainly genetic and environmental. Genetic polymorphism of cytokines like tumor necrosis factor-alpha (TNF-α) is suggestive of interference with insulin-sensitive glucose uptake and induces insulin resistance that ultimately could lead to T2DM. In this study, we assessed the effect of TNF-α (−308) G/A gene polymorphism and its association with the development of T2DM in an Ethiopian population. Methods: An institutional-based cross-sectional study was conducted on study subjects with T2DM and non-diabetic healthy controls. DNA was extracted and genotyping was carried out by using amplification refractory mutation system polymerase chain reaction. A genetic-polymorphism on TNF-α (−308) G/A with T2DM was evaluated by logistic regression and Student's t-test. A P-value Results: In the present study, we observed a significant association between T2DM and TNF-α (−308) gene polymorphism's GG genotype [χ2 test P = 0.005, OR (95% CI) =2.667 (1.309–5.45d8)]. In contrast, no statistically significant differences were observed in the frequencies of genotypes AA and AG (χ2 test P=0.132 and 0.067, respectively). Moreover, T2DM individuals had higher concentrations of lipid profiles for those carrying the TNF-α (−308) GG genotype as compared to the control group. Conclusion: TNF-α (−308) genetic polymorphism may be implicated in the genetic susceptibility for, as well as the development of T2DM and lipid metabolism in the Ethiopian population. Therefore, a large-scale study and early screening of TNF-α (−308) genetic polymorphism may help in early management and control of diabetes and related outcomes. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6886533/pdf https://www.dovepress.com/getfile.php?fileID=54306 |
| Ending Page | 2459 |
| Page Count | 7 |
| Starting Page | 2453 |
| ISSN | 11787007 |
| DOI | 10.2147/dmso.s229987 |
| Journal | Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy |
| Volume Number | 12 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2019-11-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Integrative and Complementary Medicine North West Ethiopia T2dm Tnf-α |
| Content Type | Text |
| Resource Type | Article |
| Subject | Internal Medicine Pharmacology |
