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Treatment of climacteric symptoms with an ammonium succinate-based dietary supplement: a randomized, double-blind, placebo-controlled trial
| Content Provider | Scilit |
|---|---|
| Author | Radzinskii, V. E. Kuznetsova, I. V. Uspenskaya, Y. B. Repina, N. B. Gusak, Y. K. Zubova, O. M. Burchakov, D. I. Osmakova, A. A. |
| Copyright Year | 2016 |
| Description | Peri- and postmenopausal women commonly suffer from climacteric symptoms. We evaluated the effectiveness and safety of dietary supplement Amberen to relieve vasomotor and psychosomatic symptoms during the course of a 3-month, randomized, double-blind, placebo-controlled study. General clinical assessment, evaluation using the Greene climacteric test and Spielberger–Hanin test, determination of plasma levels of gonadotropins, estradiol, leptin and apolipoproteins were used to evaluate 42–60-year-old women with vasomotor and psychosomatic menopausal symptoms. One hundred and twenty-five women were enrolled in the study and randomized between two groups. Based on the Greene test results, there was a statistically significant improvement (р < 0.05) in 13 out of 21 menopausal symptoms in women who took Amberen. During the course and by the end of the study, patients showed statistically significant changes in the levels of estradiol, gonadotropins and leptin, and decreases in body weight and waist circumference. Spielberger–Hanin test showed that Amberen stabilizes patients' psychological state with a statistically significant decrease in anxiety, increased stress resistance and improved adaptability. Comparative analysis of the vital signs measurements, blood tests and urinalysis did not show any negative effects of Amberen on the patients. Our findings indicate that Amberen can be considered a method of choice to relief mild/moderate climacteric symptoms. |
| Related Links | http://www.tandfonline.com/doi/pdf/10.1080/09513590.2016.1232686?needAccess=true |
| Ending Page | 68 |
| Page Count | 5 |
| Starting Page | 64 |
| ISSN | 09513590 |
| e-ISSN | 14730766 |
| DOI | 10.1080/09513590.2016.1232686 |
| Journal | Gynecological Endocrinology |
| Issue Number | sup2 |
| Volume Number | 32 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2016-09-30 |
| Access Restriction | Open |
| Subject Keyword | Journal: Gynecological Endocrinology Obstetrics and Gynecology Ammonium Succinate Menopause Menopausal Symptoms Treatment Mitochondrial Dysfunction Vasomotor and Psychosomatic Menopause Symptoms |
| Content Type | Text |
| Resource Type | Article |
| Subject | Endocrinology, Diabetes and Metabolism Endocrinology Obstetrics and Gynecology |
