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Diagnostic and Therapeutic Dilemmas in Rapidly Progressive Sensorineural Hearing Loss and Sudden Deafness a Reappraisal of Immune Reactivity in Inner Ear Disorders
| Content Provider | Scilit |
|---|---|
| Author | Veldman, Jan E. Hanada, Takehiro Meeuwsen, Frits |
| Copyright Year | 1993 |
| Description | Sera from 76 patients with a clinical diagnosis of idiopathic rapidly progressive sensorineural hearing loss (SNHL) (n = 15), sudden deafness (n = 31) and with other etiologies of their hearing loss (n = 30) were analysed by western blot assay. Seventy-three percent of the cases with rapidly progressive SNHL had cross-reacting antibodies (27, 45, 50, 68 kD). The overall response to immunoprogressive therapy was effective in only 50% of cases. Sixty-five percent of the patients with sudden deafness also had cross-reacting antibodies (27, 45, 50, 80 kD). In these cases steroid therapy was more effective in re-establishing the hearing than no treatment, regardless of the western blot outcome. Spontaneous recovery occurred in approx. 50% of cases, but only in those with a positive assay. The antigenic epitopes detected with immunoblotting were not cochlea specific; they were also found in protein extracts of other organs (cranial nerves, kidney, brain). |
| Related Links | http://www.tandfonline.com/doi/pdf/10.3109/00016489309135813 |
| Ending Page | 306 |
| Page Count | 4 |
| Starting Page | 303 |
| ISSN | 00016489 |
| e-ISSN | 16512251 |
| DOI | 10.3109/00016489309135813 |
| Journal | Acta Oto-Laryngologica |
| Issue Number | 3 |
| Volume Number | 113 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 1993-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Acta Oto-laryngologica Otorhinolaryngology Immunoblotting Antibodies Hearing Sudden Deafness Loss Rapidly Antigenic Reacting |
| Content Type | Text |
| Resource Type | Article |
| Subject | Otorhinolaryngology |
