NDLI: Adjunctive Rufinamide in Children with Lennox-Gastaut Syndrome: A Literature Review

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Adjunctive Rufinamide in Children with Lennox-Gastaut Syndrome: A Literature Review

Content Provider	Scilit
Author	Balagura, Ganna Riva, Antonella Marchese, Francesca Verrotti, Alberto Striano, Pasquale
Copyright Year	2020
Description	Abstract: Lennox-Gastaut syndrome (LGS) is a severe, childhood-onset, developmental epileptic encephalopathy, with different etiologies and co-morbidities. Seizure treatment in LGS represents a major challenge; new antiepileptic drugs (AEDs) are developed to especially address seizures resulting in high morbidity and mortality, such as drop seizures. Rufinamide (RFN) is one of the latest AEDs licensed for patients with LGS. Its mechanism of action involves sodium channels in a way that is unrelated to other AEDs. Here we discuss the use of adjunctive RFN in children and adolescents with LGS and its efficacy and safety profile, based on a systematic literature review. RFN shows a very favorable profile in terms of adverse events and drug-interactions in children. It is particularly effective on tonic-atonic seizures and spasms, impacting on the quality of life of the patients. Further studies are needed to clarify the interaction profile with the newest AEDs for LGS and to assess correlations between the etiology of LGS and drug response to individualize treatment and maximize efficacy.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7008198/pdf https://www.dovepress.com/getfile.php?fileID=55909
Ending Page	379
Page Count	11
Starting Page	369
ISSN	11766328
e-ISSN	11782021
DOI	10.2147/ndt.s185774
Journal	Neuropsychiatric disease and treatment
Volume Number	16
Language	English
Publisher	Informa UK Limited
Publisher Date	2020-02-01
Access Restriction	Open
Subject Keyword	Journal: Neuropsychiatric Disease and Treatment Psychiatry and Mental Health Lennox-gastaut Children Epilepsy Rufinamide
Content Type	Text
Resource Type	Article

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