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Pre-cesarean Staphylococcus aureus nasal screening and decolonization: a prospective randomized controlled trial
| Content Provider | Scilit |
|---|---|
| Author | Shrem, Guy Egozi, Tomer Naeh, Amir Hallak, Mordechai Walfisch, Asnat |
| Copyright Year | 2016 |
| Description | Objective: Staphylococcus aureus (S. aureus) is a common pathogen in surgical site infections (SSIs). Mupirocin ointment is an effective treatment for nasal carriers. We aimed to investigate whether screening for nasal colonization of S. aureus and treating carriers prior to a cesarean section (CS) decreases the likelihood of SSI. Methods: Randomized controlled trial. All participants underwent nasal culture prior to the CS. Nasal carriers of S. aureus were treated with Mupirocin ointment according to a standardized protocol. In the control group, nasal cultures were obtained immediately prior to surgery and carriers were not treated Results: We recruited 568 patients. Demographic characteristics were comparable between the groups. S. aureus nasal colonization rates were 20.1% and 14.9% in the intervention and control groups, respectively (p=0.12). S. aureus eradication rate with Mupirocin treatment was 88%. SSI rates were similar in the intervention and control groups (13.1% vs. 12.1% respectively, p=0.78) and in treated carriers, untreated carriers, and non-carriers (7.4% vs. 13.0% vs. 13.1% respectively, p=0.69). previous CS was the only factor found to independently predict SSI (OR 2.5, CI 1.09-5.65 p=0.029). Conclusion: Pre-cesarean screening for nasal S. aureus carriage and decolonization does not appear to be an effective intervention in reducing SSI rates. |
| Related Links | http://www.tandfonline.com/doi/pdf/10.3109/14767058.2016.1152243 |
| Ending Page | 3911 |
| Page Count | 6 |
| Starting Page | 3906 |
| ISSN | 14767058 |
| e-ISSN | 14764954 |
| DOI | 10.3109/14767058.2016.1152243 |
| Journal | The Journal of Maternal-Fetal & Neonatal Medicine |
| Issue Number | 23 |
| Volume Number | 29 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2016-03-03 |
| Access Restriction | Open |
| Subject Keyword | Journal: The Journal of Maternal-fetal & Neonatal Medicine Obstetrics and Gynecology Cesarean Section Mupirocin Staphylococcus Aureus Nasal Colonization Surgical Site Infection Wound Infection |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pediatrics, Perinatology and Child Health Obstetrics and Gynecology |
