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Enhancement of reticuloendotheliosis virus‐induced bursal lymphomas by serotype 2 Marek's disease virus
| Content Provider | Scilit |
|---|---|
| Author | Aly, Mona M. Witter, Richard Fadly, Aly M. |
| Copyright Year | 1996 |
| Abstract | The effect of serotype 2 and 3 Marek's disease virus (MDV) vaccines on the pathogenesis of reticuloendotheliosis virus (REV)‐induced bursal and non‐bursal lymphomas was examined in chickens of RPRL lines $15I_{5}$ X $7_{1}$ and $6_{3}$ X 0, respectively. At hatch, chickens were vaccinated with strain 301B/1 of serotype 2 MDV or strain FC126 of turkey herpesvirus (HVT), a serotype 3 MDV and inoculated with spleen necrosis virus (SNV), a non‐defective strain of REV. In another experiment, bursas from 14‐week‐old $15I_{1}$ X $7_{1}$ chickens coinfected with strain 301B of serotype 2 MDV and SNV strain of REV at hatch were examined microscopically for REV‐induced transformed follicles by methyl green pyronin stain and for the presence of MDV by in situ hybridization. The incidence of REV‐induced bursal lymphomas was significantly higher in $15I_{5}$ X $7_{1}$ chickens vaccinated with serotype 2 MDV than in unvaccinated chickens or chickens vaccinated with HVT. On the other hand, the incidence of REV induced nonbursal lymphoma in chickens of line 63 X 0 vaccinated with serotype 2 MDV was comparable to that in unvaccinated chickens or chickens vaccinated with HVT. The average number of hyperplastic follicles in bursas from REV‐infected $15I_{5}$ X $7_{1}$ chickens was significantly higher in chickens vaccinated with serotype 2 MDV than that in unvaccinated chickens or chickens vaccinated with HVT, and the MDV was more frequently detected in REV‐transformed than in untransformed bursal follicles. Data from this study suggest that serotype 2, but not serotype 3, of MDV may enhance the development of REV‐induced bursal lymphomas, and that neither serotype 2 nor serotype 3 MDV influence the development of REV‐induced nonbursal lymphomas. The data also suggest that the enhancement effects of serotype 2 MDV on REV bursal lymphomas may be at the stage of formation of hyperplastic or transformed bursal follicles. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.1080/03079459608419122?needAccess=true |
| Ending Page | 94 |
| Page Count | 14 |
| Starting Page | 81 |
| ISSN | 03079457 |
| e-ISSN | 14653338 |
| DOI | 10.1080/03079459608419122 |
| Journal | Avian Pathology |
| Issue Number | 1 |
| Volume Number | 25 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 1996-03-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Avian Pathology Virology Virus Rev Chickens Vaccinated Mdv Serotype Bursal Lymphomas Induced Nonbursal |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Microbiology Animal Science and Zoology Food Animals |
