NDLI: Lithium In Vitro Enhances Interleukin-2 Production by T Cells from Patients with Systemic Lupus Erythematosus

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Lithium In Vitro Enhances Interleukin-2 Production by T Cells from Patients with Systemic Lupus Erythematosus

Content Provider	Scilit
Author	Kucharz, Eugene J. Sierakowski, Stanistaw J. Goodwin, James S.
Copyright Year	1993
Description	Cellular immunity is impaired in patients with systemic lupus erythematosus (SLE). A decreased production of interleukin-2 by T cells isolated from blood of patients with SLE was found. The decrease correlated with severity of the disease. It was shown that incubation in vitro of T cells with 5 mM of lithium chloride augmented interleukin-2 production. The increase in cultures of T cells from patients with SLE was higher that than in healthy individuals. It is believed that lithium increases the cytosol inositol triphosphate level and subsequently augmented impaired intracellular signal transduction in the T cells from patients with SLE.
Related Links	http://www.tandfonline.com/doi/pdf/10.3109/08923979309019728
Ending Page	523
Page Count	9
Starting Page	515
ISSN	08923973
e-ISSN	15322513
DOI	10.3109/08923979309019728
Journal	Immunopharmacology and Immunotoxicology
Issue Number	5
Volume Number	15
Language	English
Publisher	Informa UK Limited
Publisher Date	1993-01-01
Access Restriction	Open
Subject Keyword	Journal: Immunopharmacology and Immunotoxicology Immunology Lithium Sle Lupus Erythematosus Systemic Lupus Impaired Cultures of T Cells Cells From Patients
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Toxicology Pharmacology Immunology

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