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Clinical Assessment of New Topical Cream Containing Two Essential Oils Combined with Tretinoin in the Treatment of Acne
| Content Provider | Scilit |
|---|---|
| Author | Mazzarello, Vittorio Gavini, Elisabetta Rassu, Giovanna Donadu, Matthew Gavino Usai, Donatella Piu, Gabriella Pomponi, Valeria Sucato, Federica Zanetti, Stefania Montesu, Maria Antonia |
| Copyright Year | 2020 |
| Description | Background: Acne is a frequent adolescent disease characterized by inflammatory and non-inflammatory lesions whose topical treatment very often presents adverse phenomena such as irritation or resistance to antibiotics that reduce the patient's compliance. The purpose of this study is to compare a commercial product (Acnatac gel) based on clindamycin-tretinoin (CTG) with a galenic compound containing 2 essential oils (Myrtus communisL. and Origanum vulgare) and tretinoin (MOTC) to evaluate its anti-acne effectiveness and action on the microclimate of the skin. Methods: Sixty volunteers were randomly divided into an A group using MOTC and a B group, as a positive control, using CTG. The effectiveness was assessed with non-invasive skin analysis (Sebumeter, pH meter, Tewameter and Mexameter) and the counts of the number of lesions, after 15 and 30 days. Results: In both groups, there is a worsening of transepidermal water loss (TEWL) due to tretinoin. MOTC has improved, starting from 15 days of treatment, the papular erythema (p = 0.0329 vs CTG) and has reduced at all times even the rashes of retinoids present in the healthy perilesional skin (p = 0.0329 and p = 0.0017, respectively, at 15 and 30 days). Conclusion: MOTC has shown, compared to Acnatac, to have anti-acne efficacy and to possess an anti-inflammatory activity, due to essential oils, able to reduce in vivo erythematous lesions and those induced by retinoids. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073433/pdf https://www.dovepress.com/getfile.php?fileID=56744 |
| Ending Page | 239 |
| Page Count | 7 |
| Starting Page | 233 |
| ISSN | 11787015 |
| DOI | 10.2147/ccid.s236956 |
| Journal | Clinical, Cosmetic and Investigational Dermatology |
| Volume Number | 13 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2020-03-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Clinical, Cosmetic and Investigational Dermatology Integrative and Complementary Medicine Acne Essential Oils Non-invasive Skin Analysis |
| Content Type | Text |
| Resource Type | Article |
| Subject | Dermatology |
