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In Vitro Testing of Biomaterials
| Content Provider | Scilit |
|---|---|
| Author | Hollinger, Jeffrey O. |
| Copyright Year | 2011 |
| Description | One of the most daunting challenges in the development of biomaterials is to validate biocompatibility. By consensus, a biomaterial is biocompatible when that material does not cause harm. (See Chapters 1, 6, and 7) This broad consensus opinion is susceptible to the challenge: What does “cause no harm” mean? The authors of this chapter underscore that no harm, in the context of a biomaterial implanted into a patient, means that the implanted material neither promotes a sustained, chronic in§ammatory reaction nor an immunological reaction. Moreover, if that material is biodegradable, the degradation products behave likewise. The process by which a biomaterial may be validated to be biocompatible begins with a series of standard in vitro assays and progresses to a stringent set of standardized in vivo tests. The biomaterial must achieve a threshold performance level to ensure that the test material does not cause harm. Book Name: An Introduction to Biomaterials |
| Related Links | https://content.taylorfrancis.com/books/download?dac=C2009-0-18976-8&isbn=9780429148910&doi=10.1201/b11561-12&format=pdf |
| Ending Page | 176 |
| Page Count | 20 |
| Starting Page | 157 |
| DOI | 10.1201/b11561-12 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2011-11-28 |
| Access Restriction | Open |
| Subject Keyword | Book Name: An Introduction To Biomaterials Biomedical Engineering Biomaterial Threshold Opinion Biocompatible See Implanted Stringent Chapter Vitro Ammatory |
| Content Type | Text |
| Resource Type | Chapter |
