The plasma pharmacokinetics of iophenoxic and iopanoic acids in goat

Content Provider	Scilit
Author	Eason, C. T. Frampton, C. M.
Copyright Year	1992
Description	1. The comparative plasma pharmacokinetics of two organic iodine-containing compounds were evaluated in the goat for their suitability as markers in wildlife studies. 2. After oral administration of a single dose, the plasma elimination half-life for iopanoic acid was considerably more rapid (t1/2 of 1–2 days) than that of iophenoxic acid (t1/2 of 81 days). 3. Similar peak plasma concentrations were obtained after administration of iophenoxic acid (1.5 mg/kg) and iopanoic acid (25 mg/kg); however, the AU0 → ∞ for iopanoic acid at doses of 25, 50, and 100 mg/kg were 201 ± 39, 604 ± 225, and 1292 ± 721 (μg h/ml ± SD), respectively, which were less than the value of 36 600 ± 6387 for the oral administration of iophenoxic acid at 1.5 mg/kg. 4. Iophenoxic acid was chosen as a suitable marker because of its persistence at detectable concentrations in the plasma for 5 months.
Related Links	http://www.tandfonline.com/doi/pdf/10.3109/00498259209046616
Ending Page	189
Page Count	5
Starting Page	185
ISSN	00498254
e-ISSN	13665928
DOI	10.3109/00498259209046616
Journal	Xenobiotica
Issue Number	2
Volume Number	22
Language	English
Publisher	Informa UK Limited
Publisher Date	1992-01-01
Access Restriction	Open
Subject Keyword	Journal: Xenobiotica Agriculture and Animal Production Plasma Pharmacokinetics Iopanoic Acids Pharmacokinetics of Iophenoxic Acids in Goat Iophenoxic and Iopanoic
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Biochemistry Toxicology Pharmacology