NDLI: Ultrasound-Triggered Delivery of Peptides and Proteins from Microspheres

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Ultrasound-Triggered Delivery of Peptides and Proteins from Microspheres

Content Provider	Scilit
Author	Kost, Joseph
Copyright Year	2020
Description	The realization that blood sugar levels must be kept in normal limits if diabetic complications are to be avoided has led to the approach of self-regulated insulin delivery systems. Cavitation is one of several possible mechanisms through which ultrasound can interact with liquid medium. Acoustic cavitation can be considered to involve at least three discrete stages: nucleation, bubble growth and, under proper conditions, implosive collapse. The enhanced release was also observed in nonerodible systems exposed to ultrasound for which the release is diffusion-dependent. In vivo studies on a model drug have suggested the feasibility of ultrasound-mediated drug-release enhancement. The results suggest the feasibility of ultrasound to enhance the release of peptides and proteins from bioerodible and nonerodible polymers. Nucleation of bubbles occurs at weak points in the liquid, such as gas-filled crevices in suspended particulate matter, or from transient microbubbles from prior cavitation events. Book Name: Microparticulate Systems for the Delivery of Proteins and Vaccines
Related Links	https://content.taylorfrancis.com/books/download?dac=C2010-0-29490-7&isbn=9781003067542&doi=10.1201/9781003067542-16&format=pdf
Ending Page	476
Page Count	14
Starting Page	463
DOI	10.1201/9781003067542-16
Language	English
Publisher	Informa UK Limited
Publisher Date	2020-07-24
Access Restriction	Open
Subject Keyword	Book Name: Microparticulate Systems for the Delivery of Proteins and Vaccines Biomedical Engineering Insulin Ultrasound Diabetic Peptides and Proteins Delivery Cavitation Model Nucleation Nonerodible
Content Type	Text
Resource Type	Chapter

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