NDLI: Acinar Cell Carcinoma of the Pancreas

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Acinar Cell Carcinoma of the Pancreas

Content Provider	Scilit
Author	Sant'agnese, P. Anthony Di
Copyright Year	1991
Description	A case of acinar cell carcinoma of the pancreas is presented. The differential diagnosis is discussed and includes endocrine neoplasm of the pancreas (islet cell and carcinoid tumor) and a poorly differentiated adenocarcinoma. The separation of the various entities by light microscopic, histochemical, immunocytochemical, and ultrastructural methods is described. The acinar cell carcinoma characteristically is positive for pancreatic digestive enzymes by immunocytochemistry, and at the ultrastructural level zymogen-type granules can be demonstrated; these have a tendency to aggregate in the apical region of acinar structures. Clinically the acinar cell carcinoma is an aggressive malignant neoplasm that may present with a characteristic syndrome of disseminated fat necrosis. Survival is generally less than 1 year.
Related Links	http://www.tandfonline.com/doi/pdf/10.3109/01913129109016265
Ending Page	577
Page Count	5
Starting Page	573
ISSN	01913123
e-ISSN	15210758
DOI	10.3109/01913129109016265
Journal	Ultrastructural pathology
Issue Number	4-5
Volume Number	15
Language	English
Publisher	Informa UK Limited
Publisher Date	1991-01-01
Access Restriction	Open
Subject Keyword	Journal: Ultrastructural Pathology Pathology Acinar Cell Carcinoma Electron Microscopy Pancreas Ultrastructure Zymogen Granules
Content Type	Text
Resource Type	Article
Subject	Structural Biology Pathology and Forensic Medicine

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