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Confidence-Interval Construction for Rate Ratio in Matched-Pair Studies with Incomplete Data
| Content Provider | Scilit |
|---|---|
| Author | Li, Hui-Qiong Chan, Ivan S. F. Tang, Man-Lai Tian, Guo-Liang Tang, Nian-Sheng |
| Copyright Year | 2014 |
| Description | Matched-pair design is often used in clinical trials to increase the efficiency of establishing equivalence between two treatments with binary outcomes. In this article, we consider such a design based on rate ratio in the presence of incomplete data. The rate ratio is one of the most frequently used indices in comparing efficiency of two treatments in clinical trials. In this article, we propose 10 confidence-interval estimators for the rate ratio in incomplete matched-pair designs. A hybrid method that recovers variance estimates required for the rate ratio from the confidence limits for single proportions is proposed. It is noteworthy that confidence intervals based on this hybrid method have closed-form solution. The performance of the proposed confidence intervals is evaluated with respect to their exact coverage probability, expected confidence interval width, and distal and mesial noncoverage probability. The results show that the hybrid Agresti–Coull confidence interval based on Fieller's theorem performs satisfactorily for small to moderate sample sizes. Two real examples from clinical trials are used to illustrate the proposed confidence intervals. |
| Related Links | https://core.ac.uk/download/pdf/38056142.pdf http://hub.hku.hk/bitstream/10722/203437/1/Content.pdf |
| Ending Page | 568 |
| Page Count | 23 |
| Starting Page | 546 |
| ISSN | 10543406 |
| e-ISSN | 15205711 |
| DOI | 10.1080/10543406.2014.888438 |
| Journal | Journal of Biopharmaceutical Statistics |
| Issue Number | 3 |
| Volume Number | 24 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2014-05-04 |
| Access Restriction | Open |
| Subject Keyword | Journal: Journal of Biopharmaceutical Statistics Statistics and Probability Agresti–coull Interval Correlated Proportions Jeffreys Interval Incomplete Data Method of Variance Estimations Recovery Wilson Interval |
| Content Type | Text |
| Resource Type | Article |
| Subject | Statistics and Probability Pharmacology Pharmacology (medical) |
