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Cellular response of the rat brain to single doses of (137)Cs γ rays does not predict its response to prolonged 'biologically equivalent' fractionated doses.
| Content Provider | Scilit |
|---|---|
| Author | D’Agostino, Ralph B. Greene-Schloesser, Dana M. Kooshki, Mitra Payne, Valerie Wheeler, Kenneth T. Metheny-Barlow, Linda J. Robbins, Mike E. |
| Copyright Year | 2014 |
| Description | Purpose: To determine if the brain's response to single doses predicts its response to 'biologically equivalent' fractionated doses. Methods: Young adult male Fischer 344 rats were whole-brain irradiated with either single 11, 14, or 16.5 Gy doses of$ ^{137}$Cs γ rays or their 'biologically equivalent' 20, 30, or 40 Gy fractionated doses (fWBI) delivered in 5 Gy fractions, twice/week for 2, 3, or 4 weeks, respectively. At 2 months post-irradiation, cellular markers of inflammation (total, activated, and newborn microglia) and neurogenesis (newborn neurons) were measured in 40 μm sections of the dentate gyrus (DG). Results: Although the total number of microglia in the DG/hilus was not significantly different (p > 0.7) in unirradiated, single dose, and fWBI rats, single doses produced a significant (p < 0.003) increase in the percent-activated microglia; fWBI did not (p > 0.1). Additionally, single doses produced a significant (p < 0.002) dose-dependent increase in surviving newborn microglia; fWBI did not (p < 0.8). Although total proliferation in the DG was reduced equally by single and fWBI doses, single doses produced a significant dose-dependent (p < 0.02) decrease in surviving newborn neurons; fWBI did not (p > 0.6). Conclusions: These data demonstrate that the rat brain's cellular response to single doses often does not predict its cellular response to 'biologically equivalent' fWBI doses. |
| Related Links | http://europepmc.org/articles/pmc4326093?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326093/pdf |
| ISSN | 09553002 |
| e-ISSN | 13623095 |
| DOI | 10.3109/09553002.2014.933915 |
| Journal | International Journal of Radiation Biology |
| Issue Number | 9 |
| Volume Number | 90 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2014-06-17 |
| Access Restriction | Open |
| Subject Keyword | Journal: International Journal of Radiation Biology Radiology, Nuclear Medicine and Imaging Brain Irradiation Single Dose Responses Fractionated Dose Responses Inflammation Neurogenesis |
| Content Type | Text |
| Resource Type | Article |
| Subject | Radiology, Nuclear Medicine and Imaging Radiological and Ultrasound Technology |
