NDLI: Down-regulating HIF-1α by lentivirus-mediated shRNA for therapy of triple negative breast cancer

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Down-regulating HIF-1α by lentivirus-mediated shRNA for therapy of triple negative breast cancer

Content Provider	Scilit
Author	Li, Shuang Wei, Qingzhu Li, Qin Zhang, Bin Xiao, Qiang
Copyright Year	2015
Description	Hypoxia is associated with poor response to treatment in various cancers. Hypoxia inducible factor 1 (HIF-1) is a major transcription factor that mediates adaptation of cancer cells to a hypoxic environment and regulates many genes that are involved in key cellular functions, including cell immortalization, stem cell maintenance, autocrine growth/survival, angiogenesis, invasion/metastasis, and resistance to chemotherapy. HIF-1α has been considered as an attractive therapeutic target for cancer treatment, but there is limited success in this research field. In the present study, we designed a recombinant lentivirus containing HIF-1α siRNA, developed stably transfected cell lines, and tested the anticancer effects of the siRNA on cancer cells in vitro and in vivo. Our results indicated that the stable downregulation of HIF-1α reversed chemoresistance, inhibited proliferation, migration and invasion of cancer cells, and slowed down the tumor growth in breast cancer xenograft models. In conclusion, the recombinant lentivirus containing HIF-1α siRNA provides a new avenue for developing novel therapy for triple negative breast cancer.
Related Links	https://www.tandfonline.com/doi/pdf/10.1080/15384047.2015.1040958?needAccess=true https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622682/pdf
Ending Page	875
Page Count	10
Starting Page	866
ISSN	15384047
e-ISSN	15558576
DOI	10.1080/15384047.2015.1040958
Journal	Cancer Biology & Therapy
Issue Number	6
Volume Number	16
Language	English
Publisher	Informa UK Limited
Publisher Date	2015-04-20
Access Restriction	Open
Subject Keyword	Journal: Cancer Biology & Therapy Biochemistry and Molecular Biology Apoptosis Gene Therapy Hif-1α Recombinant Lentivirus Sirna Therapy Stably Transfected Cell Lines Triple Negative Breast Cancer
Content Type	Text
Resource Type	Article
Subject	Cancer Research Pharmacology Molecular Medicine Oncology

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