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Serum omentin-1, inflammation and carotid atherosclerosis in patients with non-diabetic chronic kidney disease
| Content Provider | Scilit |
|---|---|
| Author | Şengül, Erkan Duygulu, Gokhan Dindar, Sevim Bunul, Fatih |
| Copyright Year | 2013 |
| Description | Background and aim: Omentin-1 is suggested to affect inversely atherosclerosis (AS). Data about omentin-1 is limited to chronic kidney disease (CKD). Our aim was to examine omentin-1 in non-diabetic CKD patients who are not dialyzed and investigate its relationships with inflammation and carotid AS. Materials and Methods: We performed a cross-sectional study in 55 non-diabetic CKD patients and 30 healthy controls. Baseline clinical and laboratory data were obtained for all participants. Serum omentin-1 and interleukin-6 (IL-6) levels were measured according to the manufacturer's instructions. Carotic plaque and intima-media thickness (IMT) were assessed by carotid ultrasonography. The homeostasis model assessment of insulin resistance index (HOMA-IR) was used to assess IR. Results: Omentin-1 and IL-6 levels in the patient group were found to be higher than the control group; the differences were statistically significant (p = 0.01 and p = 0.04, respectively). Carotid IMT(mean) was significantly higher in the patient group (p = 0.01). Omentin-1 did not correlate with IL-6 and IMT in the patient group (p = 0.51 and p = 0.76, respectively). In subgroup analysis, omentin-1 levels in patients with carotid plaque were lower than those without carotid plaque (179.5 ± 88.1 ng/ml and 185.9 ± 67.8 ng/ml, respectively). However, the difference was not statistically significant (p = 0.47). Conclusion: We conclude that omentin-1 is higher in not dialyzed non-diabetic CKD and there is no correlation between omentin-1 and IL-6 or carotid IMT(mean). |
| Related Links | http://www.tandfonline.com/doi/pdf/10.3109/0886022X.2013.817256?needAccess=true |
| Ending Page | 1093 |
| Page Count | 5 |
| Starting Page | 1089 |
| ISSN | 0886022X |
| e-ISSN | 15256049 |
| DOI | 10.3109/0886022x.2013.817256 |
| Journal | Renal Failure |
| Issue Number | 8 |
| Volume Number | 35 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2013-07-19 |
| Access Restriction | Open |
| Subject Keyword | Journal: Renal Failure Medical Laboratory Technology Atherosclerosis Chronic Kidney Disease Inflammation Omentin-1 Il-6 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Critical Care and Intensive Care Medicine Nephrology |
