NDLI: Toxicogenomics of iron oxide nanoparticles in the nematode C. elegans

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Toxicogenomics of iron oxide nanoparticles in the nematode C. elegans

Content Provider	Scilit
Author	Gonzalez-Moragas, Laura Yu, Si-Ming Benseny-Cases, Núria Stürzenbaum, Stephen Roig, Anna Laromaine, Anna
Copyright Year	2017
Description	We present a mechanistic study of the effect of iron oxide nanoparticles (SPIONs) in Caenorhabditis elegans combining a genome-wide analysis with the investigation of specific molecular markers frequently linked to nanotoxicity. The effects of two different coatings were explored: citrate, an anionic stabilizer, and bovine serum albumin, as a pre-formed protein corona. The transcriptomic study identified differentially expressed genes following an exposure to SPIONs. The expression of genes involved in oxidative stress, metal detoxification response, endocytosis, intestinal integrity and iron homeostasis was quantitatively evaluated. The role of oxidative stress was confirmed by gene expression analysis and by synchrotron Fourier Transform infrared microscopy based on the higher tissue oxidation of NP-treated animals. The observed transcriptional modulation of key signaling pathways such as MAPK and Wnt suggests that SPIONs might be endocytosed by clathrin-mediated processes, a putative mechanism of nanotoxicity which deserves further mechanistic investigations.
Related Links	https://kclpure.kcl.ac.uk/ws/files/74045514/Toxicogenomics_of_iron_oxide_nanoparticles_in_the_nematode_C_elegans.pdf
Ending Page	657
Page Count	11
Starting Page	647
ISSN	17435390
e-ISSN	17435404
DOI	10.1080/17435390.2017.1342011
Journal	Nanotoxicology
Issue Number	5
Volume Number	11
Language	English
Publisher	Informa UK Limited
Publisher Date	2017-05-28
Access Restriction	Open
Subject Keyword	Journal: Nanotoxicology Toxicology Toxicogenomics Nanotoxicity C. Elegans Iron Oxide Nanoparticles Protein Corona
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Toxicology Biomedical Engineering

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