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Total body-surface area as a new prognostic variable in mycosis fungoides and Sézary syndrome
| Content Provider | Scilit |
|---|---|
| Author | Novelli, Silvana García-Muret, Pilar Mozos, Anna Sierra, Jorge Briones, Javier |
| Copyright Year | 2016 |
| Description | Mycosis fungoides and Sézary syndrome (MF/SS) are the most common forms of primary cutaneous T cell lymphomas. We analyzed the applicability of the cutaneous lymphoma international prognostic index (CLIPi) in MF/SS. We introduced the total body-surface area affected (TBSA) and the type of skin lesions at diagnosis as prognostic variables. The overall survival (OS) at median time of follow up (96 months) was 75.6% (CI 95%, 62.0–98.5%). In the univariate analysis, age >60 years, advanced disease, type of skin lesions and TBSA >50 showed poorer OS (p < 0.05). In the multivariate analysis there was a significant increased relative risk of death in those patients >60 years, with advanced disease and TBSA >50% (p < 0.05). TBSA identified a group of poor prognosis patients with advanced MF/SS that may benefit from novel systemic therapies. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.3109/10428194.2015.1057894 |
| Ending Page | 1066 |
| Page Count | 7 |
| Starting Page | 1060 |
| ISSN | 10428194 |
| e-ISSN | 10292403 |
| DOI | 10.3109/10428194.2015.1057894 |
| Journal | Leukemia & Lymphoma |
| Issue Number | 5 |
| Volume Number | 57 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2016-05-03 |
| Access Restriction | Open |
| Subject Keyword | Journal: Leukemia & Lymphoma Dermatology Clipi Cutaneous T-cell Lymphoma Mycosis Fungoides Prognosis Sézary Syndrome |
| Content Type | Text |
| Subject | Hematology Cancer Research Oncology |
