NDLI: Delayed processing of bone marrow samples reveals a prognostic pattern ofNMEmRNA expression in cytogenetically normal acute myeloid leukemia

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Delayed processing of bone marrow samples reveals a prognostic pattern ofNMEmRNA expression in cytogenetically normal acute myeloid leukemia

Content Provider	Scilit
Author	Bach, Enrica Krahl, Rainer Lange, Thoralf Schüler, Frank Al-Ali, Haifa Kathrin Büchner, Thomas Haferlach, Torsten Dölken, Gottfried Niederwieser, Dietger Cross, Michael
Copyright Year	2012
Description	Improvements in the therapy of cytogenetically normal acute myeloid leukemia (CN-AML) will depend largely on the characterization of functional subtypes identified by prognostic markers. Exposing leukemic cells to stress ex vivo may reveal relevant phenotypic markers not apparent in freshly explanted cells. Here, we assess the prognostic relevance of expression of the nucleoside diphosphate kinase genes NME1 and NME2 in a cohort of 78 patients with CN-AML aged < 60 years using archived mononuclear cell samples originally prepared from bone marrow either directly (n = 25) or following 2–3 days of transport (n = 53). The stress conditions arising during transport resulted in the development of a prognostic pattern of NME mRNA with maintenance of high NME2 mRNA being a strong indicator of increased event-free survival independent of FLT3-internal tandem duplication. Prospective analysis of CN-AML bone marrow (n = 7) confirmed that NME1 mRNA is always decreased during storage, while NME2 mRNA is either decreased or maintained. We conclude that ex vivo stress can reveal novel prognostic markers.
Related Links	https://www.tandfonline.com/doi/pdf/10.3109/10428194.2012.676176
Ending Page	1568
Page Count	8
Starting Page	1561
ISSN	10428194
e-ISSN	10292403
DOI	10.3109/10428194.2012.676176
Journal	Leukemia & Lymphoma
Issue Number	8
Volume Number	53
Language	English
Publisher	Informa UK Limited
Publisher Date	2012-04-02
Access Restriction	Open
Subject Keyword	Journal: Leukemia & Lymphoma Hematology Aml Nme Nm23 Prognosis Normal Karyotype
Content Type	Text
Resource Type	Article
Subject	Hematology Cancer Research Oncology

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