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Statistical Comparison of Two Methods of Dissolution of Sustained-Release Theophylline Tablets
| Content Provider | Scilit |
|---|---|
| Author | Boscá, M. T. Marín Hinojosa, J. Ollero Claramonte, M. D. Contreras Salem, Ismail |
| Copyright Year | 1996 |
| Description | A comparative study of two methods of dissolution (Simoons Apparatus and USP XXII Apparatus II) has been accomplished using sustained-release 50 mg anhydrous theophylline tablets. Sovic® 374 MB, Eudragit® RL PM, Aquacoat®, Methocel® K-15M, and Cutina® HR were some of the excipients used to elaborate inert, hydrophilic, and lipidic matrices. Theophylline release was prolonged in all cases, except when Aquacoat was used as matrix constituent. Simoons device was found to be more accurate for inert matrix tablets, whereas USP apparatus was advantageous for hydrophilic and lipidic matrix. ANOVA showed significant differences among all the factors analyzed. The drug release kinetics was adjusted better to Higuchi's kinetic model than to the Noyes-whitney or Weibull models, from 10% to 70% release. |
| Related Links | http://www.tandfonline.com/doi/pdf/10.3109/03639049609063213 |
| Ending Page | 601 |
| Page Count | 7 |
| Starting Page | 595 |
| ISSN | 03639045 |
| e-ISSN | 15205762 |
| DOI | 10.3109/03639049609063213 |
| Journal | Drug Development and Industrial Pharmacy |
| Issue Number | 7 |
| Volume Number | 22 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 1996-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Drug Development and Industrial Pharmacy Pharmacology and Pharmacy Statistical Comparison Theophylline Tablets Release Theophylline Sustained Release |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Drug Discovery Pharmacology Pharmaceutical Science |
